We have recently published 4 papers in the past few months! Please go check them out below:

1) Karki, A.; Campbell, K. B.; Mozumder, S.; Fisher, A. J.; Beal, P. A. Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1. Biochemistry 2024, DOI: 10.1021/acs.biochem.3c00405

Agya and co-workers show the biochemical characterization of a number of ADAR1 deaminase domain mutants linked to a Aicardi Goutieres Syndrome through in vitro activity and binding assays. Congratulations to all involved in this project!


2) Mendoza H.G, Beal P.A. Structural and functional effects of inosine modification in mRNA. RNA 2024; DOI:10.1261/rna.079977.124

Herra discusses the role the inosine modification at different locations in the mRNA lead to human disorders. Congratulations on this fantastic review Herra!


3) Wong B.L, Mendoza HG, Jacobsen CS, Beal PA. RNA sequences that direct selective ADAR editing from a SELEX library bearing 8-azanebularine. Bioorg Med Chem 2024; DOI: 10.1016/j.bmc.2024.117700

Bailey and co-workers were able to uncover ADAR2 guide RNA’s from a SELEX screen that direct specific editing to a target site with little to no off-target editing. Congratulations to all involved in this project!


4) Jauregui-Matos, V.; Jacobs, O.; Ouye, R.; Mozumder, S.; Salvador, P. J.; Fink, K. D.; Beal, P. A. Site-Specific Regulation of RNA Editing with Ribose-Modified Nucleoside Analogs in ADAR Guide Strands. Nucleic Acids Res. 2024, DOI: 10.1093/nar/gkae461.

Victorio and co-workers were able to regulate ADAR1 and ADAR2 editing in vitro and in cellulo with a newly synthesized ribose-modified nucleoside analog placed at the guide strand. Congratulations to all involved in this project!