Prince was awarded the R.B Miller Research, Service, and Mentorship Award! Congratulations to him on this well deserved award!
Natalie delivered a fantastic third year seminar! Congratulations Natalie!
Congratulations to those involved in publishing two chapters in Methods of Enzymology detailing our work on ADAR crystallography and high-throughput guide RNA screening! Check them out here:
Crystallography chapter by Campbell, K et al.: DOI: 10.1016/bs.mie.2024.11.023
EMERGe chapter by Salvador, P et al.: DOI: 10.1016/bs.mie.2024.11.030
We are so excited that two first years, Olivia and Paul, have joined our lab!
Manjunath, A.; Cheng, J.; Campbell, K.B.; Jacobsen, C.S.; Mendoza, H.G.; Bierbaum, L.; Jauregui-Matos, V.; Doherty, E.E.; Fisher, A.J.; Beal, P.A. Nucleoside Analogs in ADAR Guide Strands Enable Editing at 5′-GA Sites. Biomolecules 2024, 14, 1229. DOI: 10.3390/biom14101229
Aash and coworkers discuss enabling editing using nucleobase modifications at challenging-to-edit sites in vitro and in mamallian cells! Congratulations to all that were involved with this project!
Congratulations to Victorio, Olivia and Megan for winning awards at our Chemistry Department Award Ceremony last friday! Victorio (5th year graduate student) was awarded the David and Ruth Volman Graduate Fellowship. We are so very proud of you and are excited for what you bring back after your internship!
Olivia (undergraduate student) was awarded the Larock Outstanding Senior Award and Department Citation for Outstanding Graduating Students, and Megan (undergraduate student) was warded the Department Citation for Outstanding Graduating Students. We have all had the pleasure of watching both of you grow as scientists during your time here in the Beal lab! We will see you in the fall during lab rotations and we are excited to witness what is sure to be a very bright future for you both!
We have recently published 4 papers in the past few months! Please go check them out below:
1) Karki, A.; Campbell, K. B.; Mozumder, S.; Fisher, A. J.; Beal, P. A. Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1. Biochemistry 2024, DOI: 10.1021/acs.biochem.3c00405
Agya and co-workers show the biochemical characterization of a number of ADAR1 deaminase domain mutants linked to a Aicardi Goutieres Syndrome through in vitro activity and binding assays. Congratulations to all involved in this project!
2) Mendoza H.G, Beal P.A. Structural and functional effects of inosine modification in mRNA. RNA 2024; DOI:10.1261/rna.079977.124
Herra discusses the role the inosine modification at different locations in the mRNA lead to human disorders. Congratulations on this fantastic review Herra!
3) Wong B.L, Mendoza HG, Jacobsen CS, Beal PA. RNA sequences that direct selective ADAR editing from a SELEX library bearing 8-azanebularine. Bioorg Med Chem 2024; DOI: 10.1016/j.bmc.2024.117700
Bailey and co-workers were able to uncover ADAR2 guide RNA’s from a SELEX screen that direct specific editing to a target site with little to no off-target editing. Congratulations to all involved in this project!
4) Jauregui-Matos, V.; Jacobs, O.; Ouye, R.; Mozumder, S.; Salvador, P. J.; Fink, K. D.; Beal, P. A. Site-Specific Regulation of RNA Editing with Ribose-Modified Nucleoside Analogs in ADAR Guide Strands. Nucleic Acids Res. 2024, DOI: 10.1093/nar/gkae461.
Victorio and co-workers were able to regulate ADAR1 and ADAR2 editing in vitro and in cellulo with a newly synthesized ribose-modified nucleoside analog placed at the guide strand. Congratulations to all involved in this project!
Congratulations Charles!
