Beal Lab

Nucleic Acid Chemistry & Chemical Biology

Congratulations to Victorio, Olivia and Megan!

Congratulations to Victorio, Olivia and Megan for winning awards at our Chemistry Department Award Ceremony last friday! Victorio (5th year graduate student) was awarded the David and Ruth Volman Graduate Fellowship. We are so very proud of you and are excited for what you bring back after your internship!
Olivia (undergraduate student) was awarded the Larock Outstanding Senior Award and Department Citation for Outstanding Graduating Students, and Megan (undergraduate student) was warded the Department Citation for Outstanding Graduating Students. We have all had the pleasure of watching both of you grow as scientists during your time here in the Beal lab! We will see you in the fall during lab rotations and we are excited to witness what is sure to be a very bright future for you both!

Recent Publications!

We have recently published 4 papers in the past few months! Please go check them out below:

1) Karki, A.; Campbell, K. B.; Mozumder, S.; Fisher, A. J.; Beal, P. A. Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1. Biochemistry 2024, DOI: 10.1021/acs.biochem.3c00405

Agya and co-workers show the biochemical characterization of a number of ADAR1 deaminase domain mutants linked to a Aicardi Goutieres Syndrome through in vitro activity and binding assays. Congratulations to all involved in this project!


2) Mendoza H.G, Beal P.A. Structural and functional effects of inosine modification in mRNA. RNA 2024; DOI:10.1261/rna.079977.124

Herra discusses the role the inosine modification at different locations in the mRNA lead to human disorders. Congratulations on this fantastic review Herra!


3) Wong B.L, Mendoza HG, Jacobsen CS, Beal PA. RNA sequences that direct selective ADAR editing from a SELEX library bearing 8-azanebularine. Bioorg Med Chem 2024; DOI: 10.1016/j.bmc.2024.117700

Bailey and co-workers were able to uncover ADAR2 guide RNA’s from a SELEX screen that direct specific editing to a target site with little to no off-target editing. Congratulations to all involved in this project!


4) Jauregui-Matos, V.; Jacobs, O.; Ouye, R.; Mozumder, S.; Salvador, P. J.; Fink, K. D.; Beal, P. A. Site-Specific Regulation of RNA Editing with Ribose-Modified Nucleoside Analogs in ADAR Guide Strands. Nucleic Acids Res. 2024, DOI: 10.1093/nar/gkae461.

Victorio and co-workers were able to regulate ADAR1 and ADAR2 editing in vitro and in cellulo with a newly synthesized ribose-modified nucleoside analog placed at the guide strand. Congratulations to all involved in this project!

New Group Photo!

Charles Advances to Candidacy!

Congratulations Charles!


Christine Tang Joins the Beal Lab!

Group Photo at Holiday Party!

Congratulations to Dr. Casey Jacobsen!

Casey graduates from Beal lab with his Ph.D!

Agya and Victorio at Oligonucleotide Therapeutics Society Meeting

Agya and Victorio at their poster presentations! Congratulations to Victorio on winning a poster prize!


Congratulations to Agyaa fantastic talk!



Congratulations to Dr. Herra Mendoza

Congratulations to Dr. Herra Mendoza for graduating and ringing the bell at the Graduate Studies office! We look forward to having you as a postdoctoral scholar in the laboratory!

Rett Syndrome Research Trust Highlights Beal Lab!

Link to article: 

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