Students and postdocs working in the Beal laboratory use synthetic chemistry to study and control ribonucleic acids (RNAs). Our work is advancing understanding of essential basic science principles of RNA structure and recognition and is providing a platform for the development of new medicines targeting RNA or RNA-binding proteins. We create new RNA molecules by chemical synthesis with nucleoside analogs, introducing novel and desirable features. In addition, we synthesize new compounds capable of perturbing natural RNA function or the function of RNA-modifying enzymes. We are currently applying these approaches to the study of RNA-editing adenosine deaminases and RNA interference by short interfering RNAs (siRNAs).
For a detailed description of this work, please visit our “Projects” link